Titlebook: Epigenetics and Disease; Pharmaceutical Oppor Susan M. Gasser,En Li Book 2011 Springer Basel AG 2011 DNA methylation.cancer.neuronal disord

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Genome-Wide Epigenetic Modifications in Cancer,cing a revolution in the strategies used to measure epigenetic alterations, which includes the incorporation of next generation sequencing tools. We also will review strategies that utilize epigenetic information for translational purposes, with a special emphasis on the potential use of DNA methyla

Mere仅仅

DNA Repair and the Control of DNA Methylation,thylation across their genomes, reflecting an underlying epigenetic instability that may have contributed to carcinogenesis. The phenotype of unstable methylation in cancer illustrates the importance of quality control in the DNA methylation system and implies the existence of proof-reading mechanis

MIME

Errors in Erasure: Links Between Histone Lysine Methylation Removal and Disease,emoved from the chromatin template. We describe how these “erasure” mechanisms are linked to pathways that are known to be misregulated in diseases, such as cancer. We further describe how errors in the removal of histone methylation can and do lead to human pathologies, both directly and indirectly

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Transcriptional Regulatory Networks in Embryonic Stem Cells,lso beginning to unravel the transcriptional regulatory networks that govern the ESC identity. Loss-of-function RNAi screens also identified novel regulatory molecules involved in the stable propagation of the ESC state. This argues for an ESC transcriptional regulation program in which interconnect