Titlebook: Enzyme Kinetics in Drug Metabolism; Fundamentals and App Swati Nagar,Upendra A. Argikar,Donald Tweedie Book 2021Latest edition Springer Sci

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Methods in Molecular Biologyhttp://image.papertrans.cn/e/image/313090.jpg

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https://doi.org/10.1007/978-1-0716-1554-6Kinetic models; Drug-drug interactions; Drug metabolizing enzymes; Regulatory guidelines; Drug transport

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Africa-EU Partnership on Energy major cause of clinically significant drug–drug interactions. This chapter defines the four reversible mechanisms of inhibition exhibited by drugs: competitive, noncompetitive, uncompetitive, and mixed competitive/noncompetitive. An in vitro procedure to determine the potential of a drug to be a re

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A. M. Vasiliev,D. A. Degterev,T. M. Shawt a million compared to the rate of the same reaction in the absence of the enzyme. In contrast to traditional catalytic enzymes, the family of cytochrome P450 (CYPs) enzymes are catalytically promiscuous and thus they possess remarkable versatility in substrates. The great diversity of reactions ca

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Célestine L. D. Mangue,Jean Gonondoe. In all but the very simplest in vitro system, these drug concentrations can be influenced by a variety of nonspecific binding reservoirs that can reduce the available concentration to the enzyme system(s) under investigation. As a consequence, the apparent kinetic parameters, such as . or ., that

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Imperialism and U.S.-Africa Relationsf their crystallographic protein structures. Fortunately, despite low sequence similarity between different families of drug-metabolizing CYPs, there exists a high degree of structural homology within the superfamily. This similarity in the protein fold allows for a direct comparison of the structur

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https://doi.org/10.1007/978-1-349-06218-8hey translocate drugs, as well as endogenous molecules and toxins, across membranes using ATP hydrolysis, or ion/concentration gradients. In general, drug transporters are expressed ubiquitously, but they function in drug disposition by being concentrated in tissues such as the intestine, the kidney