Titlebook: Entry Inhibitors in HIV Therapy; Jacqueline D. Reeves,Cynthia A. Derdeyn Book 2007 Birkhäuser Basel 2007 AIDS.HIV.HIV Therapy.HIV infectio

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Auswirkungen auf die Zivilgesellschaft,fastest evolving among many other human pathogens. Viral heterogeneity is one of the classical means by which HIV evades the host immune system, and also leads to the resistance to various antiretroviral regimens. Highly active antiretroviral therapy to treat HIV-infected patients is mainly based on

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https://doi.org/10.1007/978-3-662-60570-7tiated by specific binding interactions between glycoproteins in the viral envelope and appropriate receptors on the cell surface. In the case of HIV-1, attachment of virions to the cell surface is attributed to a high affinity interaction between envelope spike glycoproteins (Env, composed of the s

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https://doi.org/10.1007/978-3-322-83568-0s. However, four classes (nucleoside/nucleotide and non-nucleoside reverse transcriptase, protease, and fusion inhibitors) including 24 approved drugs are still inadequate and treatment failures continue to occur. Factors contributing to such failures include: the emergence of drug-resistant strains

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