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Titlebook: Engineering Mineralized and Load Bearing Tissues; Luiz E. Bertassoni,Paulo G. Coelho Book 2015 The Editor(s) (if applicable) and The Autho

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https://doi.org/10.1007/978-1-349-07780-9ion, we have developed a novel three-dimensional cell manipulation method designated the “organ germ method”. This method involves compartmentalisation of epithelial and mesenchymal cells at a high cell density to mimic multicellular assembly conditions and epithelial-mesenchymal interactions in org
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Engineering Pre-vascularized Scaffolds for Bone Regenerationternative to address this challenge has been the fabrication of pre-vascularized scaffolds by taking advantage of biomanufacturing techniques, such as soft- and photo-lithography or 3D bioprinting, and cell-based approaches, where functional capillaries are engineered in cell-laden scaffolds prior t
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Morphogenic Peptides in Regeneration of Load Bearing Tissuessoluble ECM proteins such as bone sialoprotein and enamel matrix proteins, and those peptides derived from vasculoinductive and neuro-inductive proteins. Although these peptides show significant osteogenic activity in vitro and increase mineralization and bone formation in animal models, they are no
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Multiphasic, Multistructured and Hierarchical Strategies for Cartilage Regenerationrated interplay of biomechanical properties, unique hierarchical structures, extracellular matrix (ECM), and bioactive factors. In fact, the main challenge in cartilage tissue engineering is to design an engineered device able to mimic the highly organized zonal architecture of articular cartilage,
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Hard-Soft Tissue Interface Engineeringcal and mechanical cues over sub millimetre length scales. Naturally, this complicates the manufacture of the scaffolds and every stage of their subsequent cell seeding and growth, as each region has different optimal conditions. Given the higher degree of difficulty associated with replicating inte
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Amelogenin in Enamel Tissue Engineeringres is being questioned based on the results demonstrating the ability of amelogenin to promote the nucleation and crystal growth of apatite under constant titration conditions designed to mimic those present in the developing enamel matrix. The role of numerous minor components of the enamel matrix
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Whole Tooth Regeneration as a Future Dental Treatmention, we have developed a novel three-dimensional cell manipulation method designated the “organ germ method”. This method involves compartmentalisation of epithelial and mesenchymal cells at a high cell density to mimic multicellular assembly conditions and epithelial-mesenchymal interactions in org
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