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Titlebook: Endotoxin Induced-Shock: a Multidisciplinary Approach in Critical Care; Silvia De Rosa,Gianluca Villa Book 2023 The Editor(s) (if applicab

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发表于 2025-3-21 20:06:51 | 显示全部楼层 |阅读模式
书目名称Endotoxin Induced-Shock: a Multidisciplinary Approach in Critical Care
编辑Silvia De Rosa,Gianluca Villa
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概述Focused on endotoxic shock and on specific clinical aspect and medical clinical management of endotoxemia.Highlights clinical management of endotoxic shock according to conventional therapies.Points o
图书封面Titlebook: Endotoxin Induced-Shock: a Multidisciplinary Approach in Critical Care;  Silvia De Rosa,Gianluca Villa Book 2023 The Editor(s) (if applicab
描述.This book provides easy consultation and guidance for an appropriate understanding and management of endotoxic shock. Endotoxic shock results from a severe, generalized inflammatory response induced by bloodstream infection with gram-negative bacteria. However, endotoxin-induced inflammatory activation may be disconnected by Gram-Negative threats (e.g. Gram-Positive and yeast infections) as well as occur in multiple clinical scenarios like post-cardiac arrest syndrome and trauma, possibly due to gut barrier dysfunction and consequent endotoxin translocation...The clinical management is structured focusing and dedicating a chapter for antibiotics, corticosteroids, volume support, vasoactive and cardiostimulating drug, coagulopathy and nutritional support. In addition, this book is remarkable because describing polymixin b hemoperfusion points out molecular interactions, and hydrodynamics of Sorption...Each section includes •) brief pathophysiology; •) principles of management; •) key messages. Readers can find updated tips related to the diagnosis and management of endotoxic shock with a multidisciplinary approach drawing a pathway from endotoxin structure and source and the relate
出版日期Book 2023
关键词Blood purification therapy; Critical Care; Endotoxin Acitivity; Polymixin B hemoperfusion; Septic Shock
版次1
doihttps://doi.org/10.1007/978-3-031-18591-5
isbn_softcover978-3-031-18593-9
isbn_ebook978-3-031-18591-5
copyrightThe Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerl
The information of publication is updating

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发表于 2025-3-21 23:25:06 | 显示全部楼层
Pathophysiology of Endotoxic Shock,the bacterial cell. It is recognized as a pathogen-associated molecular pattern and its recognition by pattern recognition receptors activates the inflammatory response. The consequent release of proinflammatory cytokines and chemokines triggers the classical manifestations of the antimicrobial and
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Host Resistance to Endotoxic Shock,endotoxin exposure may induce a state of immunosuppression, namely “endotoxin tolerance,” that balances hyperinflammation and may protect the host from the development of endotoxic shock. In this setting, endotoxin tolerance may be considered a model of epigenetic modification and complex gene repro
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Endotoxin and Organ Cross-Talk,auses of mortality and morbidity in intensive care units worldwide. The emergence of progressively multidrug-resistant pathogens and the gradual drying up of the antibiotic pipeline have led the fight against pathogens to reach critical proportions. Sepsis results from a heterogeneous interaction of
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Clinical Management of Endotoxemia: Antibiotics,ntervention may be associated with potential harms as well as challenged by concurrent patient and pathogen characteristics that may limit its efficacy. For these reasons, antimicrobic choice should be driven by evidence-based stewardship programs that take into account the severity of organ dysfunc
发表于 2025-3-22 19:53:54 | 显示全部楼层
Clinical Management of Endotoxemia: Volume Support,s a key role in endotoxic shock, with the aim of balancing resuscitation thus avoiding additional harm. Many types of solutions are available for fluid administration. Currently, some study groups promote the use of intravenous . solutions whilst chloride administration may impact on renal function
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Clinical Management of Endotoxemia: Source Control,l may include drainage of an abscess, debriding infected necrotic tissue, removal of a potentially infected device, or definitive control of a source of ongoing microbial contamination. The timing and adequacy of source control are important in the management of intra-abdominal infections; late and/
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