Titlebook: Endothelin and Its Inhibitors; Timothy D. Warner Book 2001 Springer-Verlag Berlin Heidelberg 2001 Circulation.Endothelin.Glatte Muskulatur

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,Die Ökonomisierung der Sozialen Arbeit,nt the contractile actions of norepinephrine, 5-HT, and angiotensin II, it has been proposed that ET-1 also sensitizes vessels to the actions of other “classical” circulating neurohumoral factors (MacLean and McGrath 1990; Lerman et al. 1991; Nakayama et al. 1991).

悬崖

Historical Perspective and Introduction to the Endothelin Family of Peptides,sts. However, EDRF was not prostacyclin. Obviously, the regulatory mechanism of vascular tone involved several chemical substances, which are produced and released from endothelial cells in response to various physical and chemical stimuli and act on the underlying smooth muscle cells to elicit relaxation.

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评论性

The Involvement of Endothelins in Cerebral Vasospasm and Stroke,ible therapeutic potential. The isolation, purification and sequencing of the endothelins has since allowed the development of both peptide and non peptide antagonists selective for endothelin receptors (see Chap. 9).

建筑师

Vascular and Cardiac Effects of Endothelin,nt the contractile actions of norepinephrine, 5-HT, and angiotensin II, it has been proposed that ET-1 also sensitizes vessels to the actions of other “classical” circulating neurohumoral factors (MacLean and McGrath 1990; Lerman et al. 1991; Nakayama et al. 1991).

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Endothelin-1 and Pulmonary Hypertension,se of a narrowing or loss of pulmonary microvessels, due to an increase in vascular tone (i.e., vasoconstriction), remodelling, with hypertrophy of medial and intimal layers and muscularization of small arterioles (Voewkel and Weir 2000), or destruction of vascular channels.

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Book 2001diseases. Attention is also paid to the development through chemistry, pharmacology and toxicology of endothelin antagonists and endothelin-converting enzyme inhibitors, with mention of all the important members of these drug classes. This leads to well-rounded discussions of the potential therapeutic benefit of endothelin inhibitors.