| 书目名称 | Endoplasmic Reticulum Stress in Health and Disease | | 编辑 | Patrizia Agostinis,Samali Afshin | | 视频video | | | 概述 | Comprehensive cover of the latest developments in ER stress.Up to date and succinct description of the role of ER stress in pathophysiology.Novel aspects of ER stress physiology never discussed before | | 图书封面 |  | | 描述 | The Endoplasmic Reticulum (ER) is an organelle with extraordinary signaling and homeostatic functions. It is the organelle responsible for protein folding, maturation, quality control and trafficking of proteins destined for the plasma membrane or for secretion into the extracellular environment. Failure, overloading or malfunctioning of any of the signaling or quality control mechanisms occurring in the ER may provoke a stress condition known as ‘ER stress’. Accumulating evidence indicates that ER stress may dramatically perturb interactions between the cell and its environment, and contribute to the development of human diseases, ranging from metabolic diseases and cancer to neurodegenerative diseases, or impact therapeutic outcome. This book primarily focuses on the pathophysiology of ER stress. It introduces the molecular bases of ER stress, the emerging relevance of the ER-mitochondria cross-talk, the signaling pathways engaged and cellular responses to ER stress, including the adaptive Unfolded Protein Response (UPR), autophagy as well as cell death. Next the book addresses the role of ER stress in physiology and in the etiology of relevant pathological conditions, like carci | | 出版日期 | Book 2012 | | 关键词 | Cell Death; Diseases; ER stress; Inflammation; Unfolded Protein response; Apoptosis | | 版次 | 1 | | doi | https://doi.org/10.1007/978-94-007-4351-9 | | isbn_softcover | 978-94-007-9251-7 | | isbn_ebook | 978-94-007-4351-9 | | copyright | Springer Science+Business Media Dordrecht 2012 |
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发表于 2025-3-21 18:53:11
