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Titlebook: Endocrine Therapy of Breast Cancer; Current Developments Franco Cavalli Book 1987Latest edition Springer-Verlag Berlin Heidelberg 1987 brea

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https://doi.org/10.1007/978-3-642-72983-6breast cancer; cancer; chemotherapy; clinical trial; oncology
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First Person Suspect, or, the Enemy Within …Hormone receptors in human breast cancer have been the matter of widespread biochemical and clinical investigations during the last 15 years. A large number of laboratories and oncology departments have published data demonstrating the advantage of these measurements in the selection of the most appropriate treatments.
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Introduction: The Terms of the QuestionSome aspects of the methodology of clinical trials were discussed in the ESO Monograph published last year [1]. The concept of statistical evidence, trial design and sample size considerations, endpoint selection, and issues for adjuvant disease, advanced disease and prevention studies were covered.
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Preliminary Assessment of New Methodologies in the Determination of Hormonal Receptors,Hormone receptors in human breast cancer have been the matter of widespread biochemical and clinical investigations during the last 15 years. A large number of laboratories and oncology departments have published data demonstrating the advantage of these measurements in the selection of the most appropriate treatments.
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Evaluating the Benefits of Therapies for Breast Cancer,Some aspects of the methodology of clinical trials were discussed in the ESO Monograph published last year [1]. The concept of statistical evidence, trial design and sample size considerations, endpoint selection, and issues for adjuvant disease, advanced disease and prevention studies were covered.
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Evaluation Criteria in Comparative Clinical Trials in Advanced Breast Cancer: A Proposal for ImprovClinical trials in metastatic breast cancer and other presently incurable diseases may have three basically different aims:
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Adjuvant Chemotherapy in Premenopausal Patients: A More Complicated Form of Oophorectomy?,etrospective analyses of some of the other trials which tested the effect of chemotherapy have shown amenorrhea to be associated with increased DFS and OS. The type of alkylating agent used in these trials (cyclophosphamide), the dose of drug and the compliance with prescribed treatment might influence the degree of suppression of ovarian function.
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