Titlebook: Electric Cell-Substrate Impedance Sensingand Cancer Metastasis; Wen G. Jiang Book 2012 Springer Science+Business Media Dordrecht 2012 Canc

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Protein Kinase C Isoforms in the Formation of Focal Adhesion Complexes: Investigated by Cell Impeda in numerous cellular functions, including cellular proliferation, apoptosis, adhesion, migration, and monolayer integrity. PKC isoforms are thought to modulate cellular function through enzymatic phosphorylation of substrates, however few have been identified. We will review the evidence demonstrat

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Electrical Cell-Substrate Impedance Sensing for Measuring Cellular Transformation, Migration, Invas increased proliferation, loss of contact inhibition and attachment, and the ability to form tumors in mice. Electrical cell substrate impedance sensing (ECIS) is the measurement of resistance and reactance across an electrode containing the growing cells. As they grow, the characteristics of transf

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Epithelial-Mesenchymal Transition and the Use of ECIS,ed in tumour cell invasion may aid in limiting tumour progression and lead to a reduction in patient mortality. In order to become invasive, tumour cells must overcome the physical barriers imposed by cell–cell adhesions and the basement membrane and attain a motile phenotype. Evidence is emerging w

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Tight Junctions in Cancer Metastasis and Their Investigation Using ECIS (Electric Cell-Substrate Imining cell to cell integrity. Loss of cohesion of the TJ structure can lead to invasion and ultimately to the metastasis of cancer cells. Modulation of expression of TJ molecules results in key changes in TJ barrier function leading to the progression of cancer and progression of metastasis. This ch

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Tumour-Endothelial and Tumour-Mesothelial Interactions Investigated by Impedance Sensing Based Cellactive area pursued for the past decades. However, methods to investigate tumour-endothelial interactions mostly are tedious and lack of high throughput capability. Similarly, tumour-mesothelial interactions are also important part of the transcoelomic spreading in the body cavities. However, method

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Application of Electric Cell-Substrate Impedance Sensing in Evaluation of Traditional Medicine on todels and reliable and predictive methods. This brief chapter explores the use electric cell-substrate sensing (ECIS) in evaluation of the effect of traditional Chinese medicine ., commonly used in patients with cancer in China including gastrointestinal malignancies, on the cellular functions of ga

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Electric Cell-Substrate Impedance Sensing as a Screening Tool for Wound Healing Agents,s simplicity of setup in cell culture. However, with the emerging needs of acquiring high sensitivity and achieving high-throughput in cell behavior study, researchers in life science started to apply electric cell-substrate impedance sensing (ECIS) technology, with its automated real-time impedance

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ECIS, Cellular Adhesion and Migration in Keratinocytes,teins and molecules on wound healing. Keratinocytes undertake epithelialisation during the process of wound healing, and understanding their function, and their regulating factors, is important in understanding why some wounds fail to heal. This chapter will detail the physiology behind wound healin