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Titlebook: EJB Reviews 1996; P. Christen,E. Hofmann Book 1997 Springer-Verlag Berlin Heidelberg 1997 Biochemie.Biophysik.Molekularbiologie.Peptide.bi

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,The ,A4 amyloid precursor protein gene and Alzheimer’s disease, characteristics is .A4 amyloid deposition in senile plaques in the brain parenchyma and in cerebral blood vessels. .A4 amyloid is processed from a larger integral membrane protein, the .A4 amyloid precursor protein. Different pathogenic mutations in this protein have been detected in a small number
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Oxygenic photosynthesis,nt-protein complexes to oxidise water and produce NAD(P)H. The protein environment provides a scaffold in the membrane on which cofactors are placed at optimum distance and orientation, ensuring a rapid, efficient trapping and conversion of light energy. The polypeptide core also tunes the redox pot
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DNA-replication fidelity, mismatch repair and genome instability in cancer cells,tation rate, thus providing a pool of mutants upon which selection could act to yield a tumor. Such a mutator phenotype could result from a defect in any of several DNA transactions, including those that determine the DNA replication error rate or the ability to correct replication errors. Recent ev
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The role of controlled proteolysis in cell-cycle regulation,active cyclin-dependent kinases, determines the substrate specificity of the enzymes. Cyclin-dependent-kinase inhibitors have an adverse effect, blocking the catalytic activity of cyclin-activated cyclin-dependent kinases. The cell cycle is a cyclic process of successive transient activation or inac
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The regulation of human immunodeficiency virus type-1 gene expression, Recent research is, however, revealing some of the secrets of the replication cycle of this complex retrovirus, and this may lead to the development of novel antiviral compounds. In particular the virus uses strategies for gene expression that seem to be unique in the eukaryotic world. These involv
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