Titlebook: Dynamics and the Problem of Recognition in Biological Macromolecules; Oleg Jardetzky,Jean-François Lefèvre Book 1996 Springer Science+Busi

figure

偶然

Allergy, Addiction, Preference and Prejudiceixed-front-fanged poisonous snakes. These toxins bind competitively to the post-synaptic acetylcholine receptor (AChR), blocking nerve transmission and effectively inducing paralysis. This ability to block nerve transmission makes them pharmcologically interesting, and they have also proven to be va

Myofibrils

Allergy, Addiction, Preference and Prejudicermodynamic (Jardetzky and Roberts, 1981; Feeney and Birdsall, 1993). For protein-ligand complexes of relatively modest size (<30kD), the use of nuclear Overhauser effect measurements and isotope-labelling can lead to the determination of a complete three-dimensional structure of the complex, in just

conflate

极大的痛苦

Allergy, Addiction, Preference and Prejudice by off-pathway misfolding steps, and that the rate-limiting step is the reorganization necessary to correct the misfolding. When folding is fast in the absence of a misfolding-reorganization barrier, the rate-limiting step appears to be the initial molecular collapse. Available evidence suggests th

FOLD

Allergy, Addiction, Preference and Prejudice- to moderate-sized proteins, nucleic acids, oligosaccharides, and molecular complexes (Wüthrich, 1986; Clore and Gronenborn, 1991). The fundamental phenomenon that allows the extraction of three-dimensional structural information from NMR studies is cross relaxation between protons (Neuhaus and Wil

清楚说话

Allergy, Addiction, Preference and Prejudiceof barnase in aqueous solvent. The cooperative nature of the unfolding transition and the important role of water are described. The folding calculation are based on a bead model of the protein on a cubic lattice. It is shown for the 27-mer model that a large energy gap between the lowest energy (na

maculated

Hyperplasia

Allergy, Addiction, Preference and Prejudicers, the static aspects of proteins have been emphasized, primarily because this technique can only characterize relatively rigid and completely folded proteins. On the other hand, NMR can study partially folded proteins and can characterize well internal motions. Among the most fruitful techniques t

赞美者

Allergy, Addiction, Preference and Prejudicepathogens, the immune system has evolved a network of regulatory mechanisms that distinguish between self and non-self at the molecular level. Three proteins of this network play a key role in this process, by interacting directly with antigens. These proteins are the antibody, the T cell receptor (