Titlebook: Dynamic Hyperpolarized Nuclear Magnetic Resonance; Thomas Jue,Dirk Mayer Book 2021 Springer Nature Switzerland AG 2021 chemical shift imag

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Handbook of Modern Biophysicshttp://image.papertrans.cn/e/image/283608.jpg

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Dynamic Hyperpolarized Nuclear Magnetic Resonance978-3-030-55043-1Series ISSN 2698-380X Series E-ISSN 2698-3818

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N,ctral domains. Nonrecoverable multinuclear magnetization is the feature of hyperpolarized magnetic resonance (MR) with the greatest impact on how different elements of MR pulse sequences can be used. This chapter introduces the features of hyperpolarized .C MR metabolic imaging and the pulse sequences used to optimally sample these data.

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https://doi.org/10.1007/978-3-030-55043-1chemical shift imaging; enzyme activity; hyperpolarizable molecules; kinetic modeling; signal sampling

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Kinetic Modeling of Enzymatic Reactions in Analyzing Hyperpolarized NMR Data,, underlying enzyme kinetics, and chemical exchange processes. In this chapter, we review these effects and discuss approaches currently used to quantify in vivo data. Quantitation is of particular importance for comparing results across sites and informing on the underlying pathologies.

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Innovating Metabolic Biomarkers for Hyperpolarized NMR,here biomarkers derived from imaging the metabolism of hyperpolarized .C-labelled substrates could influence clinical management. The barriers to clinical translation and their potential solutions will also be addressed.