Titlebook: Drug-Induced Pathology; E. Grundmann (Professor, Dr.) Conference proceedings 1980 Springer-Verlag Berlin Heidelberg 1980 Arzneimittelneben

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Jeff Kennington,Eli Olinick,Dinesh Rajanrly high blood through-put, in fact some 25% of the coronary output, and because it is the major site for the elimination of many pharmaceutical preparations, this organ is particularly predisposed to drug-dependent damage. Drug-induced damage of the kidney is facilitated by a number of aspects of r

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Michael Buettner,David WetherallThe diagnostic assumption of drug-induced renal damage presupposes a causal and/or temporal relationship between the ingestion of a particular drug or drugs and the appearance of the symptoms. Demonstration of a causal relationship is often complicated by the ingestion of several potentially nephrotoxic drugs (. et al. 1976).

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Michael Buettner,David WetherallIn 1956, . and . defined hypokalemic nephropathy as a new entity characterized clinically by potassium depletion and morphologically by vacuolar degeneration of the renal tubules.

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Michael Buettner,David WetherallToday more than ever, drug-induced effects and diseases are gaining in significance. Two factors seem to be largely responsible for this development:

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Epidemiological Observation on Drug-Induced Illness,The increase in the use of drugs for both short-term and long-term treatment during the past decades has led to a corresponding increase in concern about their potential for inducing serious illnesses. As a result, the search for drug-induced disorders has achieved a high priority in medical research (. 1976; . 1976).

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