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Titlebook: Drug-Induced Headache; Hans-Christoph Diener (Prof. of Neurology),Marcia Conference proceedings 1988 Springer-Verlag Berlin Heidelberg 19

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Drug-Induced Headache — Does a Critical Dosage Exist?a gradual increase in frequency and dose of drug intake, eventually ending in daily administration of high dosages. It is unknown whether the daily intake itself or the drug dosage plays the crucial role.
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Ergotism — The Clinical Pictureent types of headache. Ergotism is, however, very frequent. Andersson (1973) stated that 10% of headache patients in his clinic had ergotism symptoms. The picture has not changed to this day. Wilkinson (1985) reported that 4% of patients coming to the City of London Migraine Clinic in the years 1976–1981 had ergotism symptoms.
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Platelet Reactivity in Ergotamine Headache Compared to Migraine and Muscle Contraction Headacheatelet function is still unknown (Kruglak et al. 1984). Abnormal platelet reactivity could represent a side effect of migraine (Deshmuk and Meyer 1977), it could be a pure epiphenomenon (Rose 1985), or it may be an important step in the evolution of a migraine headache (Hannington et al. 1981).
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978-3-642-73329-1Springer-Verlag Berlin Heidelberg 1988
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hat there should be a medicine or medicines which give them instant relief. In the search for the compound which would meet this very natural desire, many drugs have been manufactured and the temptation for the physician is either to increase the dose of a drug which seems to be, at any rate, partia
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