Titlebook: Drug Treatment in Obstetrics; A Handbook of Prescr R. S. Ledward,D. F. Hawkins Book 1983 R.S. Ledward and D.F. Hawkins 1983 fetus.newborn.o

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and ,: The Question of AllusionThere is no direct evidence that vaccination with killed or attenuated live vaccines against influenza, tetanus, cholera and yellow fever has any ill effect on the pregnant woman unless she has an allergic or idiosyncratic reaction.

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Implications of Adopting Modern TechnologyCaution and care are necessary in giving drugs to the newborn. On each occasion, the absolute necessity for the drug, whether or not its side effects in . are known, the appropriateness of the dose for the baby’s weight and the frequency of administration must be questioned.

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Prescribing in pregnancy: drugs and the fetus,Most drugs cross the placenta by simple diffusion from a high to a low concentration and the rate of transfer is related to the concentration gradient, the thickness and surface area of the membrane and to the diffusion constant for the substance being transferred.

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Drugs and breast feeding,The characteristics of a drug which influence the rate and amount excreted in breast milk include its protein binding capacity — only those molecules not bound to protein are available for transfer. Other factors include the degree of ionisation of the drug at its physiological pH. Drugs may gain access to the milk by one of three mechanisms:

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Book 1983nician. Rodney Ledward first discussed this project with me some years ago, and it seemed to me at the time that with his background as both a pharmaceutical chemist and an obstetrician that his talents were particularly well suited to this task. In conjunction with Professor Hawkins, he has produce