Titlebook: Drug Target Selection and Validation; Marcus T. Scotti,Carolina L. Bellera Book 2022 The Editor(s) (if applicable) and The Author(s), unde

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Target Identification Approaches in Drug Discovery,covered by phenotypic-based screening methods. However, identifying molecular targets for these bioactive compounds is a very laborious process. With the development and advancements in new methodologies and techniques for identification and biological analysis, various target identification methods

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Introduction to Target Validation,riteria of drug target candidates. The selection of molecular targets with the highest potential for developing selective, effective and safe drugs depends, to a significant extent, on the correct assessment of their structural, biochemical and biological properties. The validation of a molecular ta

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Structure-Based Binding Pocket Detection and Druggability Assessment,odulation will interfere with disease progression, or at least alleviate disease symptoms. In addition to verifying the association between such biomolecules and the disease, target validation often involves the assessment of some relevant properties, . among them..Druggability is often defined as t

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Network-Based Target Identification,ounds. However, identification of drug targets by experiments is usually expensive and time-consuming. Therefore, various types of computational methods have been developed for prediction of drug targets over the past decade, such as molecular docking-based, pharmacophore-based, similarity-based, ma

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The Current State of Precision Medicine and Targeted-Cancer Therapies: Where Are We?,at may occur in an individual’s tumor. The goal of precision medicine is simply to deliver the right treatment to the right patient at the right dose and the right time..Precision medicine involves the collection and validation of population-wide data, including multi-omics molecular profiling data

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