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Titlebook: Drug Resistance in Leishmania Parasites; Consequences, Molecu Alicia Ponte-Sucre,Emilia Diaz,Maritza Padrón-Niev Book 20131st edition Sprin

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https://doi.org/10.1007/978-1-349-00207-8prognosis, and for control of the disease. The present chapter offers a description of American tegumentary leishmaniasis, a fundamental piece of knowledge for the comprehension of the challenges we face for leishmaniasis in times of drug resistance. As a way to better understand the unique scenario
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https://doi.org/10.1007/978-1-349-00207-8ociation of these proteins with drug resistance in leishmaniasis and its fundamental role in the pathology and pharmacology of this medically important protozoan parasite that currently infects around 12 million people in the world.
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https://doi.org/10.1007/978-1-349-00207-8antioxidant pathways, e.g., nonprotein thiols, protects parasites from antimony-mediated oxidative stress. Indeed, in antimony-resistant strains, the increased biosynthesis of trypanothione (a bis(glutathionyl)spermidine conjugate, T[SH]2), the major intracellular thiol of . parasites, occurs, follo
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,Introduction: Leishmaniasis – The Biology of a Parasite,ues for better treatments may help improve this depressing picture. Experts in the field cover current knowledge and future trends of these and many other aspects of drug resistance in . in the present volume. This part offers a general introduction to the biology of ., a piece of knowledge fundamen
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The Role of Reservoirs: Canine Leishmaniasis develop clinical manifestations. This fact cannot be ignored since asymptomatic dogs are infectious to phlebotomine vectors, although at a lower risk than symptomatic dogs. Moreover, dogs never achieve parasitological cure. This fact and the widespread use of the available anti-. drugs for both can
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Epidemiology of Leishmaniasis in the Time of Drug Resistanceented, with a particular emphasis on their relation with parasite drug resistance. The focus of this chapter is on antimonials since we have most experience in the field and in the lab with them. Although these drugs are currently being abandoned as first-line treatment in the Indian subcontinent, w
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