Titlebook: Drug Discovery in Japan; Investigating the So Sadao Nagaoka Book 2019 Springer Nature Singapore Pte Ltd. 2019 Drug discovery.breakthrough.u

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Freud, the Subconscious and Virginia Woolf Pharmaceutical. Compared to earlier antihypertensive drugs, candesartan had a new mechanism of action, fewer side effects, and demonstrated efficacy even at low doses. The research project started as exploratory research on diuretics. Takeda discovered CV-2198, the first nonpeptidic ARB, by making

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https://doi.org/10.1007/978-94-007-5748-6apan. It is also the first antibody drug developed in Japan. Chugai Pharmaceuticals started the basic research on autoimmune disease early, when neither a target molecule nor a disease mechanism was known. The research and development program was long and uncertain, taking 24 years to acquire the ap

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https://doi.org/10.1007/978-94-007-6149-0. The new gene (PD-1), its function, and the possibility that its suppression can be used to block cancer growth were identified in the laboratory of Prof. Tasuku Honjo at Kyoto University, starting from a serendipitous basic science discovery. Despite concrete demonstrations by Honjo’s team of the

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https://doi.org/10.1007/978-981-13-8906-1Drug discovery; breakthrough; uncertainty; delegated initiative; competition; Statin; Opdivo

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often incomplete when discovery starts, requiring sustained .This book analyzes the drug-discovery process in Japan, based on detailed case studies of 12 groups of 15 innovative drugs. It covers the first statin in the world up to the recent major breakthrough in cancer therapy, the recent immune ch