Titlebook: Drug Discovery and Evaluation: Pharmacological Assays; Franz J. Hock Living reference work 20200th edition

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Overview of the Vestibular System %) can be given. These so-called EC150-values facilitate the insulin-independent comparison of the relative potency of the insulin-like activity between compounds/drug candidates, in general, and in particular for those frequently observed stimuli, which do not elicit the same maximal response in %

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https://doi.org/10.1007/978-88-470-0640-9for or characterization of drug candidates affecting or leaving unaffected those pathways. For this, both the oxygen consumption rate (OCR), which primarily reflects mitochondrial respiration, and the extracellular acidification rate (ECAR), which primarily reflects lactic acid production (glycolysi

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Drug Discovery and Evaluation: Pharmacological Assays

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Acne Models,m the smooth endoplasmic reticulum are formed, participating in the synthesis of lipids which appear as droplets of varying size (Karasek 1968; Morohashi 1968). Following an increase of lipid droplets, the cells increase in size, become totally differentiated, and are pushed toward the apex of the g

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Anti-Parkinson Activity, stores by reserpine and after treatment with phenothiazines and other antipsychotic drugs blocking dopamine receptors (Vernier 1964; Marsden et al. 1975; Duvoisin 1976; Hornykiewicz 1975; Miller and Hiley 1975). The pathology of Parkinson’s disease is typified by the presence of cytoplasmic inclusi

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