| 书目名称 | Drug Discovery and Evaluation: Methods in Clinical Pharmacology |
| 编辑 | Franz J. Hock,Michael R. Gralinski |
| 视频video | |
| 概述 | A landmark in the continuously changing world of drugs.Easy-to-use, method-orientated overview on all aspects of Clinical Pharmacology.Essential reading for pharmacologists, physicians, medicinal chem |
| 图书封面 |  |
| 描述 | .Drug Discovery and Evaluation has become a more and more difficult, expensive and time-consuming process. The effect of a new compound has to be detected by in vitro and in vivo methods of pharmacology. The activity spectrum and the potency compared to existing drugs have to be determined..As these processes can be divided up stepwise we have designed a book series "Drug Discovery and Evaluation" in the form of a .recommendation. document. The methods to detect drug targets are described in the first volume of this series "Pharmacological Assays" comprising classical methods as well as new technologies. Before going to man, the most suitable compound has to be selected by pharmacokinetic studies and experiments in toxicology. These preclinical methods are described in the second volume „Safety and Pharmacokinetic Assays". Only then are first studies in human beings allowed. Special rules are established for Phase I studies. Clinical pharmacokinetics are performed in parallel with human studies on tolerability and therapeutic effects. Special studies according to various populations and different therapeutic indications are necessary. These items are covered in the third volume: „M |
| 出版日期 | Living reference work 20200th edition |
| 关键词 | Assays; drug action; drugs; clinical pharmacology; pharmacodynamics; pharmacokinetics |
| doi | https://doi.org/10.1007/978-3-319-56637-5 |
| isbn_ebook | 978-3-319-56637-5 |
发表于 2025-3-21 19:28:18
