Titlebook: Drug Development; Molecular Targets fo Timothy S. Gaginella,Antonio Guglietta Book 2000 Springer Science+Business Media New York 2000 cytok

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Ute Winkels,Yoko Schlütermann-Sugiyaman then be metabolized via several enzymes to yield a vast array of vasoactive and immunomodulatory substances, termed “eicosanoids” (Fig. 1). Included in this group are the prostaglandins (PGs), leukotrienes (LTs) and thromboxanes (TXs). In general, eicosanoids have a short half-life (seconds to min

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Ute Winkels,Yoko Schlütermann-Sugiyamasiologic roles for NO have been identified, including those of a vasodilator, neurotransmitter, antimicrobial agent, immunomodulator, and intracellular signaling molecule (Moncada et al., 1991; Moncada and Higgs, 1995; Whittle, 1994). It can be formed in a wide range of cell types, such as the endot

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https://doi.org/10.1007/978-3-663-11747-6nes (CKs) are involved in essentially all of these GI disorders, but they play a particularly dominant role in illnesses whose clinical symptoms are the result of immune-mediated, persistent inflammatory processes. Typical examples include chronic gastritis, celiac disease (gluten-sensitive enteropa

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Einführung in die Problemstellungand differentiation. In contrast to the classical hormones that are produced and secreted by specific cells, PGFs are usually synthesized by cells of a variety of different tissues, and often exert their pharmacological effects on target cells located not far from the site of release (paracrine resp

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Einführung in die Problemstellung different from any of the endogenous compounds known at that time. Quantitative estimations of the novel principle were made by comparing the activity of extracts with the effect of a standard preparation referred to as “P” on the tracings and in the protocols, so that, since 1934, the term “substa

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Hans-Hermann Braess,Ulrich Seiffert step has been the development of potent and specific peptide receptor antagonists, which not only became important experimental tools for elucidating the physiological roles of peptide hormones, but also in defining the contribution of peptide hormones to disease states, but they may even ultimatel

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Hans-Hermann Braess,Ulrich Seiffertfor the focus on 5-HT is its strategic location in enterochromaffin cells (Erspamer, 1996) which are in close proximity to the mucosal sensory nerve endings, and in interganglionic neurons, which synapse on motor excitatory and motor inhibitory neurons (Gershon and Ross, 1966; Gershon, 1977; Furness

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978-1-61737-087-8Springer Science+Business Media New York 2000