Titlebook: Drug Allergy; Clinical Aspects, Di Brian A. Baldo,Nghia H. Pham Book 2021Latest edition Springer Nature Switzerland AG 2021 drug allergies.

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Mechanisms of Hypersensitivity,anaphylaxis. Urticaria is a heterogeneous disease with many subtypes. Both ACE inhibitors and angiotensin II receptor blockers may cause angioedema. Abacavir changes the shape of the HLA antigen-binding cleft producing an alteration in the repertoire of self-peptides that bind HLA-B*57:01 and a T ce

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Diagnosis of Allergic Reactions to Drugs, In anaphylaxis, the ratio of total to mature tryptase is typically less than 10. Given the technical improvements made with BAT and the test’s validation for a number of drugs, it continues to be applied to many drug reactions. Non-proliferation-based in vitro assays of cell surface activation mark

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,β-Lactam Antibiotics,de chain remaining from the original molecule. With some allergic patients, the R2 side chain and/or the whole cephalosporin molecule is also recognized by IgE antibodies. Testing with penicillins does not reliably predict cephalosporin allergy unless the side chains of the penicillin and the culpri

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Drugs and Other Agents Used in Anesthesia and Surgery,xes. Allergic and other adverse reactions to the hypnotics/induction agents thiopentone, propofol, midazolam, and ketamine are rare, and this is also the case for the antifibrinolytics tranexamic acid, ε-aminocaproic acid, and etamsylate. True IgE-mediated reactions to local anesthetics are extremel

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Corticosteroids,the CSs into three groups: (i) those that produce most of the allergic reactions – CSs that are non-methylated and usually non-halogenated; (ii) halogenated molecules with a C16/C17 .-ketal/diol structure; and (iii) CSs that produce allergy rarely – halogenated and C16-methylated CSs. Anti-inflammat

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Proton Pump Inhibitors,ge testing have been the only procedures employed to routinely diagnose immediate reactions to PPIs. A suitable test for the detection of PPI-specific IgE antibodies is not yet available, and application of the basophil activation test has been limited. A surprising number and diverse range of PPI-r