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Titlebook: Drug Addiction; From Basic Research Rao S. Rapaka,Wolfgang Sadée Book 2008 Springer-Verlag New York 2008 Addiction.Basic.Cannabinoid.Chemo

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https://doi.org/10.1007/978-3-662-10798-0existence of a dual deficit in DA and 5-HT function during withdrawal from chronic cocaine or alcohol abuse. Then we summarize studies that have tested the hypothesis that 5-HT neurons can dampen the effects mediated by mesolimbic DA. For example, it has been shown that pharmacological manipulations
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Rao S. Rapaka,Wolfgang SadéeProvides a comprehensive overview of physiological, biochemical, and genetic pathways underlying drug addiction, and resultant efforts to develop novel treatment strategies dealing with drug addiction
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Low Cost-3D Visualization of Neural Networksadditional neurotransmitters, including glutamate, serotonin and adenosine. All these neurotransmitters regulate the phosphorylation state of Dopaminal serine/threonine protein phosphatase, PP-1. Phosphorylatine- and cAMP-regulated phosphoprotein, Mr 32kDa (DARPP-32). Phosphorylation at Thr. by prot
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https://doi.org/10.1007/978-3-662-10798-0 activated. Many vital physiological events such as sensory perception, immune defense, cell communication, chemotaxis, and neurotransmission are mediated by GPCRs. Not surprisingly, GPCRs are major targets for drug development today. Most modeling studies in the GPCR field have focused upon the cre
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