Titlebook: Drosophila Models for Human Diseases; Masamitsu Yamaguchi Book 2018 Springer Nature Singapore Pte Ltd. 2018 Gene function.Drug screen.Meta

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Obligatory

Diseases Associated with Mutation of Replication and Repair Proteins,ure ageing, skeletal disorders, mental retardation, microcephaly, and neurodegeneration. . has orthologues of most human replication and repair proteins and high conservation of the relevant cellular pathways, thus providing a versatile system in which to study how these pathways are corrupted leadi

有特色

Models to Investigate Insulin Action and Mechanisms Underlying Human Diabetes Mellitus,tem that maintains constant glucose levels in blood. It is accomplished by two hormones, insulin and glucagon acting antagonistically. Insulin is produced in β cells in pancreas and secreted to blood. It specifically binds to its receptors on plasma membrane and activates the intracellular signaling

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抛媚眼

Humanized Flies and Resources for Cross-Species Study,cilitates the sharing of information. However, it is still challenging to predict the pathogenicity of missense mutations, and it is more difficult to evaluate the functional impact of noncoding variants. What is more, it is a primary question to understand what variants interact to express phenotyp

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watertight,

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Serenity

Therapie als System. Entwurf einer Theorieomics). Yet missing is advanced metabolomics technologies like isotope-assisted metabolomics optimized for .. In this chapter, we will discuss on the current status and future perspectives in technologies and applications of . metabolomics.

Transfusion

Amyotrophic Lateral Sclerosis Model, each of the ALS genes can contribute to uncovering pathophysiological mechanism of ALS and finding targets of the disease-modifying therapy. In this review, we focus on three ALS-causing genes: . (.), . (.), and . (.).