| 书目名称 | Dose-Finding Designs for Early-Phase Cancer Clinical Trials | | 副标题 | A Brief Guidebook to | | 编辑 | Takashi Daimon,Akihiro Hirakawa,Shigeyuki Matsui | | 视频video | | | 概述 | Serves as an excellent resource in the design and analysis of early phase dose-finding trials.Covers a wide range of various methods for designing early phase dose-finding clinical trials in oncology | | 丛书名称 | SpringerBriefs in Statistics | | 图书封面 |  | | 描述 | This book provides a comprehensive introduction to statistical methods for designing early phase dose-finding clinical trials. It will serve as a textbook or handbook for graduate students and practitioners in biostatistics and clinical investigators who are involved in designing, conducting, monitoring, and analyzing dose-finding trials. The book will also provide an overview of advanced topics and discussions in this field for the benefit of researchers in biostatistics and statistical science. Beginning with backgrounds and fundamental notions on dose finding in early phase clinical trials, the book then provides traditional and recent dose-finding designs of phase I trials for, e.g., cytotoxic agents in oncology, to evaluate toxicity outcome. Included are rule-based and model-based designs, such as 3 + 3 designs, accelerated titration designs, toxicity probability interval designs, continual reassessment method and related designs, and escalation overdose control designs. This bookalso covers more complex and updated dose-finding designs of phase I-II and I/II trials for cytotoxic agents, and cytostatic agents, focusing on both toxicity and efficacy outcomes, such as designs wi | | 出版日期 | Book 2019 | | 关键词 | Adaptive Design; Cancer; Dose Finding; Phase I; Phase I/II | | 版次 | 1 | | doi | https://doi.org/10.1007/978-4-431-55585-8 | | isbn_softcover | 978-4-431-55584-1 | | isbn_ebook | 978-4-431-55585-8Series ISSN 2191-544X Series E-ISSN 2191-5458 | | issn_series | 2191-544X | | copyright | The Author(s), under exclusive licence to Springer Japan KK 2019 |
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发表于 2025-3-21 16:35:02
