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Titlebook: Dopaminergic Neuron Transplantation in the Weaver Mouse Model of Parkinson’s Disease; Lazaros C. Triarhou Book 2002 The Editor(s) (if appl

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发表于 2025-3-21 19:57:13 | 显示全部楼层 |阅读模式
书目名称Dopaminergic Neuron Transplantation in the Weaver Mouse Model of Parkinson’s Disease
编辑Lazaros C. Triarhou
视频video
丛书名称Advances in Experimental Medicine and Biology
图书封面Titlebook: Dopaminergic Neuron Transplantation in the Weaver Mouse Model of Parkinson’s Disease;  Lazaros C. Triarhou Book 2002 The Editor(s) (if appl
出版日期Book 2002
关键词Parkinson; behavior; neurons; neuropeptides; phenotype
版次1
doihttps://doi.org/10.1007/978-1-4615-0699-7
isbn_softcover978-1-4613-5201-3
isbn_ebook978-1-4615-0699-7Series ISSN 0065-2598 Series E-ISSN 2214-8019
issn_series 0065-2598
copyrightThe Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Busines
The information of publication is updating

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发表于 2025-3-21 21:46:20 | 显示全部楼层
Introduction,s of the substantia nigra communicate with neurons of the basal ganglia by liberating the neurotransmitter dopamine (DA). Such an interaction at the biochemical level is responsible for the fine tuning of an organism’s movements.
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Springer Fachmedien Wiesbaden GmbH egeneration. Weaver mice represent the only known model of genetically-determined degeneration of the endogenous DA system and offer a unique opportunity to study the effects of a chronically ill environment on the fate of grafted DA neurons.
发表于 2025-3-22 11:01:53 | 显示全部楼层
Directions for Future Research,egeneration. Weaver mice represent the only known model of genetically-determined degeneration of the endogenous DA system and offer a unique opportunity to study the effects of a chronically ill environment on the fate of grafted DA neurons.
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Springer Fachmedien Wiesbaden GmbHa DA receptor agonist, causes rotation to the side contralateral to the lesion..The effect of apomorphine is presumably a result of activating a greater number of DA receptors on the side of the lesion, due to the increase in receptors as a function of denervation supersensitivity..–.
发表于 2025-3-22 21:17:18 | 显示全部楼层
Tamara Häbe,Jürgen Joos,Andreas Zendlere fact that the mesostriatal DA depletion is progressive, taking place over several months, and incomplete, in contrast with the acute degeneration characteristic of the neurotoxic models. Thus, neural transplantation studies in the weaver can address specific aspects of graft integration with the chronic pathological nervous system.
发表于 2025-3-23 03:45:24 | 显示全部楼层
Springer Fachmedien Wiesbaden GmbH of graft effects and of graft-recipient interactions at structural and functional levels, pertinent to understanding cellular mechanisms of graft action both in the basic neuroscience and in the clinical setting, where 6-L-[.F]fluorodopa uptake is used to monitor the survival of human mesencephalic grafts in Parkinsonian patients..,.
发表于 2025-3-23 08:13:02 | 显示全部楼层
Histochemical Properties of Intrastriatal Mesencephalic Grafts,e fact that the mesostriatal DA depletion is progressive, taking place over several months, and incomplete, in contrast with the acute degeneration characteristic of the neurotoxic models. Thus, neural transplantation studies in the weaver can address specific aspects of graft integration with the chronic pathological nervous system.
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