| 书目名称 | Diverse Roles of Integrin Receptors in Articular Cartilage | | 编辑 | Mehdi Shakibaei,Constanze Csaki,Ali Mobasheri | | 视频video | | | 丛书名称 | Advances in Anatomy, Embryology and Cell Biology | | 图书封面 |  | | 描述 | .Integrins belong to an evolutionary conserved family of adhesion molecules with important biological functions throughout the animal kingdom. They are heterodimeric glycoproteins involved in cell-cell and cell-matrix adhesion and communication. Physiologically they function as intra- and extracellular signalling molecules in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic spread of tumor cells. Integrin beta 1 (ß1-integrin) is a multi-functional member of the integrin superfamily and is an integral protein involved in cell-matrix adhesion, cell signalling, cellular defense, cell adhesion, protein binding, protein heterodimerization and receptor-mediated activity. The ß1-integrin family of cell surface receptors appears to play a major role in mediating cell-extracellular matrix interactions that are important in regulating these fundamental processes. ß1-integrins are important adhesion molecules that are highly expressed in articular chondrocytes where they bind to extracellular matrix molecules including fibronectin, laminin, and fibrillar collagens. In addition to mediating cell adhesion, members of the ß1 subfamily of i | | 出版日期 | Book 2008 | | 关键词 | ageing cartilage; articular cartilage; cartilage; cells; chondrocyte; chondrogenesis; collagen types I/II; | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-540-78771-6 | | isbn_softcover | 978-3-540-78770-9 | | isbn_ebook | 978-3-540-78771-6Series ISSN 0301-5556 Series E-ISSN 2192-7065 | | issn_series | 0301-5556 | | copyright | The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE |
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发表于 2025-3-21 17:41:19
