Titlebook: Disorders of Sleep and Circadian Rhythms in Parkinson‘s Disease; Aleksandar Videnovic,Birgit Högl Book 2015 Springer-Verlag Wien 2015 Circ

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Neurochemistry of the Sleep-Wake Cycle in Parkinson’s Diseaseive and negative feedback loops) mechanisms. This chapter reviews the role of each of these neurotransmitter systems in sleep-wake regulation and how degeneration of these nuclei may contribute to deficits in the sleep-wake cycle of PD patients.

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Impaired Sleep and Alertness in Parkinson’s Disease: “What Did We Learn from Animal Models?”model of PD. We complete our review by providing hypotheses on the mechanisms responsible for REM sleep behavior disorder known to occur in half of the Parkinson’s patients based on studies of RBD animal models.

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Fatigue and Sleepiness in Parkinson’s Disease Patientseffects of fatigue from the effects of other comorbid symptoms in the PD patients, such as depression and sleep problems. Fatigue and sleepiness are two distinct entities; thus, it is important to separate excessive daytime sleepiness from fatigue. Because of scant knowledge on pathophysiology and treatment, these sections are discussed briefly.

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https://doi.org/10.1007/978-3-658-41954-7ng causes and instituting recommendations that can consist of sleep hygiene and behavioral changes, alterations in the dosing and timing of PD medications, treatment of comorbid disorders, and the use of medications that affect nocturnal sleep quality and daytime alertness.

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Character-to-Number Conversion,ted to cognitive impairment in PD, whereas insomnia, sleep quality, and SDB show modest or no correlation. Further longitudinal studies are needed to determine the role of RBD, EDS, and sleep spindle abnormalities as potential markers of cognitive decline in PD.

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