| 书目名称 | Dislocation and Degradation of Proteins from the Endoplasmic Reticulum |
| 编辑 | Emmanuel Wiertz,Marjolein Kikkert |
| 视频video | |
| 概述 | Includes supplementary material: |
| 丛书名称 | Current Topics in Microbiology and Immunology |
| 图书封面 |  |
| 描述 | The present volume of Current Topics in Microbiology and Immunology c- tains seven chapters that illuminate various aspects of a protein’s genesis and terminal fate in the endoplasmic reticulum (ER). This area is of immediate medical relevance and has blossomed, to no small extent, because of the study of molecules central to the function of the immune system [immunogl- ulins, T cell receptors, major histocompatibility complex (MHC)-encoded products]. Similarly, the clever strategies used by bacteria or viruses to gain a foothold in the host and ensure their continued survival have uncovered altogether new cell biological principles. It is therefore ?tting that a special volume be devoted to the interplay between pathways of protein degradation in the ER and a wide variety of pathogens. The concept of quality control emerged with the appreciation that, in the case of multimeric glycoproteins, any unpaired glycoprotein subunit had great dif?culties leaving its site of synthesis—the ER—and was destroyed instead. Free immunoglobulin heavy chains were probably the earliest documented example of this kind, and were long known to cause pathology when their accumulation went unchecked. In |
| 出版日期 | Book 2005 |
| 关键词 | Endoplasmatisches Reticulum; Viruses; bacteria; cell; cell biology; diseases; embryology; immunology; membra |
| 版次 | 1 |
| doi | https://doi.org/10.1007/3-540-28007-3 |
| isbn_softcover | 978-3-642-42177-8 |
| isbn_ebook | 978-3-540-28007-1Series ISSN 0070-217X Series E-ISSN 2196-9965 |
| issn_series | 0070-217X |
| copyright | The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE |
发表于 2025-3-21 19:07:10
