Titlebook: Disease-modifying Therapy in Vasculitides; Cees G. M. Kallenberg,Jan W. Cohen Tervaert Book 2001 Birkhäuser Verlag 2001 Internal medicine.

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T-cell directed treatment: anti-thymocyte globulin, with a cumulative dose higher than 100 g [.]. There is a definite need to replace cyclophosphamide in these refractory cases. In other patients, standard treatment has to be avoided because severe side-effects already developed. Few patients have been reported to have responded to Cyclosporin A [.]

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Prevention of relapsing disease in anti-neutrophil cytoplasmic antibody related necrotizing small-verapy after a remission is induced with cyclophosphamide and steroids [.]. Azathioprine is considered less effective in inducing remission than cyclophosphamide, but its long-term toxicity is much lower [., .]. The potential of azathioprine as maintenance therapy was recently investigated and compar

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