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Titlebook: Discovery DMPK Quick Guide; Guide to Data Interp S. Cyrus Khojasteh,Harvey Wong,Cornelis E.C.A. Hop Book 2022 Springer Nature Switzerland A

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发表于 2025-3-21 17:23:56 | 显示全部楼层 |阅读模式
书目名称Discovery DMPK Quick Guide
副标题Guide to Data Interp
编辑S. Cyrus Khojasteh,Harvey Wong,Cornelis E.C.A. Hop
视频video
概述Highlights assays, parameters to be optimized, candidate properties, and assessment.Contains a large amount of reference data that are useful for day-to-day interpretation of ADME studies.Multi discip
图书封面Titlebook: Discovery DMPK Quick Guide; Guide to Data Interp S. Cyrus Khojasteh,Harvey Wong,Cornelis E.C.A. Hop Book 2022 Springer Nature Switzerland A
描述.This book is intended for a broad readership, in particular, those working or interested in drug discovery coming from various disciplines such as medicinal chemistry, pharmacology, drug metabolism and pharmacokinetics, bioanalysis, clinical sciences, biochemistry, pharmaceutics, and toxicology.  It provides, for the first time, a completely integrated look at multiple aspects of ADME sciences (absorption, distribution, metabolism, and excretion) in a summary format that is clear, concise, and self-explanatory.  DMPK in Drug Discovery - Guide to Data Interpretation and integration leverages the prior knowledge from the first book that covers the basics of each concept (Drug Metabolism and Pharmacokinetics Quick Guide).  This reference book is meant to be used day to day and provides many useful tables (used for data interpretation), figures, and case studies that can facilitate drug discovery.  The case studies are intended to be short and relevant to the topic discussed and present another dimension to the discussions..
出版日期Book 2022
关键词Drug discovery; Drug optimization; ADME; Drug candidate selection; Metabolic CL; Prodrug; PKPD Modeling; PB
版次1
doihttps://doi.org/10.1007/978-3-031-10691-0
isbn_softcover978-3-031-10693-4
isbn_ebook978-3-031-10691-0
copyrightSpringer Nature Switzerland AG 2022
The information of publication is updating

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发表于 2025-3-21 20:57:49 | 显示全部楼层
ADME Assays,on). The combination of fast optimization of key DMPK properties based on a target profile together with efficient bioanalytical methods has allowed for robust screening of drug candidates. For example, determining the metabolism rate . using liver microsomes or hepatocytes has allowed for the calcu
发表于 2025-3-22 02:15:41 | 显示全部楼层
Book 2022 is meant to be used day to day and provides many useful tables (used for data interpretation), figures, and case studies that can facilitate drug discovery.  The case studies are intended to be short and relevant to the topic discussed and present another dimension to the discussions..
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978-3-031-10693-4Springer Nature Switzerland AG 2022
发表于 2025-3-23 03:40:53 | 显示全部楼层
Cross-border-UnternehmensakquisitionenThis section addresses some typical DMPK questions that an ADME scientist encounters during drug discovery support. These questions are addressed by means of general concepts, experimental approaches, and examples. They are also linked to other sections for the ease of search and understanding.
发表于 2025-3-23 08:56:45 | 显示全部楼层
Visionen, Missionen und LeitbilderThis chapter is used as a reference for provided various resources as it comes to regulatory authorities. This includes the counties, codes of US federal regulations, IND sections plus various modules and notable guidance for industry by FDA.
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