| 书目名称 | Discovering and Developing Molecules with Optimal Drug-Like Properties |
| 编辑 | Allen C Templeton,Stephen R. Byrn,Thomas E. Prisin |
| 视频video | |
| 概述 | Addresses the challenge to more efficiently select better molecules for drug development.Discusses how to expand the chemical space within which a pharmacological benefit can be found.Examines the rea |
| 丛书名称 | AAPS Advances in the Pharmaceutical Sciences Series |
| 图书封面 |  |
| 描述 | .This authoritative volume provides a contemporary view on the latest research in molecules with optimal drug-like properties. It is a valuable source to access current best practices as well as new research techniques and strategies. Written by leading scientists in their fields, the text consists of fourteen chapters with an underlying theme of early collaborative opportunities between pharmaceutical and discovery sciences. The book explores the practical realities of performing physical pharmaceutical and biopharmaceutical research in the context of drug discovery with short timelines and low compound availability. Chapters cover strategies and tactics to enable discovery as well as predictive approaches to establish, understand and communicate risks in early development. It also examines the detection, characterization, and assessment of risks on the solid state properties of advanced discovery and early development candidates, highlighting the link between solid state propertiesand critical development parameters such as solubility and stability. Final chapters center on techniques to improve molecular solubilization and prevent precipitation, with particularly emphasis on lin |
| 出版日期 | Book 2015 |
| 关键词 | drug delivery; in silico; modeling; physicochemical |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-1-4939-1399-2 |
| isbn_softcover | 978-1-4939-4860-4 |
| isbn_ebook | 978-1-4939-1399-2Series ISSN 2210-7371 Series E-ISSN 2210-738X |
| issn_series | 2210-7371 |
| copyright | American Association of Pharmaceutical Scientists 2015 |
发表于 2025-3-21 19:53:41
