Titlebook: Dihydropyridines; Progress in Pharmaco Wolf-Dieter Busse (Professor),Bernward Garthoff,Fr Conference proceedings 1993 Springer-Verlag Berli

monochromatic

Twenty Years of Dihydropyridines,tory article of the January issue of . by Vater et al. [1] remain valid as pars pro toto for the DHP group of calcium antagonists. Only the overall interpretation of these data, which appeared in the discussion in that first DHP paper, should be read in a historical context, based on the knowledge of 1972.

Diuretic

Pharmacological Classification of High-Threshold Calcium Channels in Rat Neurons,entry through voltage-dependent calcium channels is also important for a whole range of phenomena triggered by increases in internal calcium levels. Among these phenomena may be cell death resulting from prolonged calcium entry subsequent to long-lasting depolarizations, as may occur during ischemia.

顶点

遗传学

Nimodipine and Nervous System Function, al. 1989). This finding may be highly relevant for nimodipine’s action, given the fact that 50% of the cells in the CNS consist of glial cells which support and modulate the function of neurones in the CNS. Finally, there are binding sites for nimodipine on CNS blood vessels which thus provide another target for the drug.

Thyroxine

陈列

HAWK

,Differenzialdiagnostik und Komorbidität,f the research management, however, the blockade of Ca. entry into the cells was most likely to be associated with severe side effects, so that Ca. antagonists were not likely to succeed. The company entered the Ca. antagonist field eventually with a licensed „me-too“ compound, but 10–15 years too late.

保留

周年纪念日

1,4-Dihydropyridines: Effects of Chirality and Conformation on Their Activity,m agonists, in this case to BAY K 8644 (Fig. 1, item 2) the best investigated example in this series [1]. After separation of the enantiomers of BAY K 8644 it was discovered that only the (-)-S-enantiomer exhibits the calcium agonistic effects, while the other antipode is still a classical antagonist [2].

周兴旺