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Titlebook: Dietary Phenylalanine and Brain Function; Richard J. Wurtman,Eva Ritter-Walker Book 1988 Birkhäuser Boston 1988 brain.metabolism.perceptio

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Effect of Aspartame on Plasma Phenylalanine Concentration in Humanshese clinical studies have examined the plasma phenylalanine response when APM was given as a bolus dose in unsweetened beverage, orange juice, a sucrose solution, capsules, or a slurry or as part of a meal. The complexity of the meal feedings ranged from soup and a beverage to a hamburger and a milk shake.
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Effects of Aspartame Ingestion on Large Neutral Amino Acids and Monoamine Neurotransmitters in the Cnhance the uptakes of these amino acids into brain and also antagonize the entry into brain of other large neutral amino acids. This article reviews evidence that such amino acid effects do occur in brain following aspartame ingestion by rats and then evaluates their impact on the rates of synthesis of the monoamine neurotransmitters.
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https://doi.org/10.1007/978-3-658-31599-3C and HVA with any of the treatments, indicating that changes in brain phenylalanine and tyrosine levels may selectively affect production of the dopamine molecules that are preferentially released into synapses.
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