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Frank Möllerer, recent studies have suggested that ATO and ATRA, or even ATO alone, used as front-line treatment of . associated APL can induce long-term remissions. This raises the possibility that some patients can be cured using differentiation therapies alone, without the need for chemotherapy, thereby pote

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Interferon-, Modulates Indoleamine Metabolism in Rat Pineal Gland in Organ Culturehat IFN-ɤ exerts dual effects on pineal indoleamine metabolism in rats: one is the suppression of NAT activity, which requires intact pineal sympathetic innervation; and the other is the enhancement of melatonin production, probably, by a suppression of oxidative deamination of 5HT.

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