Titlebook: Diagnosis of Cutaneous Lymphoid Infiltrates; A Visual Approach to Antonio Subtil Book 2019 Springer Nature Switzerland AG 2019 cutaneous ly

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Health beliefs and attributionsLymphocytic infiltrates with prominent involvement of the subcutaneous adipose tissue occur in some entities such as lupus erythematosus panniculitis (LEP), subcutaneous panniculitis-like T-cell lymphoma, and some cases of gamma-delta T-cell lymphoma. Since these entities show marked differences in prognosis, proper classification is critical.

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https://doi.org/10.1007/978-1-4899-0562-8Several immunohistochemical stains are generally performed in the evaluation of a cutaneous lymphoid infiltrate. However, the selection of stains varies significantly depending on the pattern and composition of the infiltrate. Recognition of technical problems and positivity thresholds is also important in the interpretation of special stains.

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https://doi.org/10.1007/978-1-4899-0562-8Mycosis fungoides (MF) is the most common type of skin lymphoma and classically demonstrates a CD4-positive phenotype. However, a subset of MF cases is CD8-positive. Some aggressive lymphomas are CD8-positive and must be differentiated from indolent processes, such as lymphomatoid papulosis type D.

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Differential Diagnosis of Large Cell InfiltrateAtypical cutaneous lymphoid infiltrates composed of large cells are uncommon. The differential diagnosis for this pattern includes predominantly aggressive lymphomas; however, indolent conditions such as CD30-positive lymphoproliferative disorders should also be considered.

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