Titlebook: Diabetic Nephropathy; Pathophysiology and Joris J. Roelofs,Liffert Vogt Book 2019 Springer International Publishing AG, part of Springer N

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Clinical Features and Natural Course of Diabetic Nephropathytage renal failure is reached without treatment in 5–7 years. Although albuminuria is the first sign, the first symptom of diabetic nephropathy is usually peripheral edema, which occurs at a very late stage. Regular, systematic screening for diabetic kidney disease is needed in order to identify pat

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Global, Regional, and Ethnic Differences in Diabetic Nephropathyuminuric DN phenotype; African-Americans and South Asians are also more likely to progress rapidly to more advanced stages of CKD. Factors such as genetic predisposition, differing access to standard DM care, as well as suboptimal DM-related health-care spending are identified drivers for observed d

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The Genetics of Diabetic Nephropathy our increased understanding of the course of kidney disease in patients with diabetes. As the field moves forward, approaches that incorporate these advances should greatly facilitate efforts to identify variants in genes that have a major effect on the risk of DN. In this chapter, we review eviden

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Pathology of the Kidney in DiabetesThen, we move to the natural history of DKD progression and relationships between structural changes, renal dysfunction, and diabetes duration. Finally, reversal of DKD lesions following long-term normoglycemia after pancreas transplantation and animal models of DKD are discussed.

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