Titlebook: Diabetes and the Endocrine Pancreas; A Biochemical Approa William Montague Book 1983 William Montague 1983 Diabetes.Diabetes mellitus.Insul

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The Structure of the Endocrine Pancreas,ons, the head, the body and the tail. It develops from two outgrowths (diverticula) of the embryonic duodenum, one of which forms most of the head region while the other forms the remainder of the organ. These endodermal outgrowths fuse to form a typical exocrine gland connected by ducts to the gut.

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Insulin Synthesis, Storage and Secretion,atment of diabetes mellitus, but it also provided a powerful stimulus to the development of techniques for the isolation and characterisation of the biologically active molecule. Insulin was first crystallised in 1926 by J.J. Abel and at that time there was great controversy as to whether the crysta

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Insulin Action,ve been made in our understanding of the mechanism of action of insulin. These advances began in the early 1970s when it was established that the initial event in the action of insulin was its interaction with specific receptors on the plasma membrane of the target cell. This interaction has been de

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Glucagon,nitial hyperglycaemic response when injected into man. However, it was not until the 1950s that the peptide hormone glucagon was purified and its primary structure determined. The existence of purified glucagon made it possible to study in great detail the chemistry and mechanism of action of this h

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Somatostatin,terial from some fractions of the purification sequence inhibited the secretion of growth hormone. The major component with the growth hormone release-inhibiting activity was isolated, characterised and named somatostatin. It is now known that somatostatin is also present in other areas of the centr

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The Function of the Islets of Langerhans,he supply of certain nutrients in the diet, the concentration of these nutrients in the blood is maintained at a level appropriate to the varying and competing needs of the tissues of the body. This is achieved largely by alterations in the rate of secretion of the islet cell hormones into the circu

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Diabetes Mellitus,ions of the disease span a spectrum from asymptomatic glucose intolerance to symptomatic diabetes with acute metabolic derangements (ketoacidosis, hyperosmolar coma) and with chronic complications (diseases of the vascular, renal and nervous systems). It is an important clinical problem as it curren

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