Titlebook: Developments in Statistical Evaluation of Clinical Trials; Kees van Montfort,Johan Oud,Wendimagegn Ghidey Book 2014 Springer-Verlag Berlin

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Designing Multi-arm Multi-stage Clinical Studies,rovide detailed solutions for multi-arm multi-stage studies with normally distributed endpoints in which all promising treatments are continued at the interim analyses. An approach to find optimal designs is discussed as well as asymptotic solutions for binary, ordinal and time-to event endpoints.

cauda-equina

corpus-callosum

Statistical Considerations in the Use of Composite Endpoints in Time to Event Analyses,in cardiovascular disease where individuals are at increased risk of myocardial infarction, angina, or stroke. In such settings it is common for clinical trialists to adopt composite endpoints on which to base treatment comparisons. We discuss issues in the use of composite endpoints and emphasize the difficulty in interpreting measures of effect.

弯曲的人

Rejuvenate

狗窝

Design and Analysis of Clinical Trial Simulations, this chapter, we present points to consider when planning a clinical trial simulation, and discuss how to design a clinical trial simulation employing a fractional factorial design and how to analyze the simulation results.

察觉

Mindfulness in Behavioral Healthrovide detailed solutions for multi-arm multi-stage studies with normally distributed endpoints in which all promising treatments are continued at the interim analyses. An approach to find optimal designs is discussed as well as asymptotic solutions for binary, ordinal and time-to event endpoints.

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Handbook of Mindfulness and Self-Regulationtistic, and the multi-stage models for analysing competing risks data are explained. Furthermore, we apply the theoretical methodology and illustrate the fundamental problems of interpreting the results of competing risk analyses by using empirical data in the field of outcome research in orthopaedics.

attenuate

雄辩