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Titlebook: Developmental Origins of Health and Disease (DOHaD); From Biological Basi Takeo Kubota,Hideoki Fukuoka Book 2018 Springer Nature Singapore

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发表于 2025-3-21 16:36:35 | 显示全部楼层 |阅读模式
书目名称Developmental Origins of Health and Disease (DOHaD)
副标题From Biological Basi
编辑Takeo Kubota,Hideoki Fukuoka
视频video
概述Covers numerous diseases associated with DOHaD.Presents an update of our understanding of molecular mechanisms for DOHaD.Based on the latest biological data.Suggests importance of early interventions
丛书名称Advances in Experimental Medicine and Biology
图书封面Titlebook: Developmental Origins of Health and Disease (DOHaD); From Biological Basi Takeo Kubota,Hideoki Fukuoka Book 2018 Springer Nature Singapore
描述This book addresses the developmental origins of health and disease (DOHaD), a new medical concept that demonstrates that various adult diseases start in the fetal period. It discusses our current understanding of the molecular mechanisms of DOHaD, including gene body epigenetics and non-coding RNA, and comprehensively examines diseases such type 2 diabetes, a well known as standard DOHaD-associated disease, as well as non-alcoholic fatty liver disease, hypertension and neurodevelopmental disorders. It argues that most adult diseases start at a very early stage, such as in the fetal and neonatal periods, and that earlier prevention and intervention would result in better outcomes for adult diseases such as type 2 diabetes and cardiac disorders, which are increasing in both developed and developing countries. The book appeals to obstetricians and pediatricians, as well as physicians who treat adult patients, wanting to understand the origins of diseases..
出版日期Book 2018
关键词Epigenome; Pre-emptive medicine; Metabolic disease; Maternal under-nutrition; Nutritional environment
版次1
doihttps://doi.org/10.1007/978-981-10-5526-3
isbn_softcover978-981-13-3856-4
isbn_ebook978-981-10-5526-3Series ISSN 0065-2598 Series E-ISSN 2214-8019
issn_series 0065-2598
copyrightSpringer Nature Singapore Pte Ltd. 2018
The information of publication is updating

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发表于 2025-3-22 00:09:29 | 显示全部楼层
Novel Models of Epigenetic Gene Regulation in the Nutritional Environmentat epigenetic memories determine the types of differentiated cells in each tissue. Moreover, the development of metabolic diseases induced by environmental factors during development is controlled by epigenetic regulation rather than the genetic regulation such as DNA sequence-dependent transcriptio
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Epigenetic Switching and Neonatal Nutritional Environmentdingly, hepatic fatty acid β-oxidation is activated after birth to produce energy from breast milk lipids. De novo lipogenesis is induced upon the onset of oral intake, when the major nutritional source switches to carbohydrate. However, how a particular metabolic pathway is activated during the liv
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Fetal Origins of Hypertensionthe year 2015. High blood pressure, hypertension, has a multifactorial etiology. Arterial atherosclerotic changes, systolic or diastolic dysfunction of the heart, and other noncardiac factors are involved. Epidemiological evidence has revealed that perinatal growth disturbance elevates the prevalenc
发表于 2025-3-22 15:32:14 | 显示全部楼层
Involvement of Noncoding RNAs in Stress-Related Neuropsychiatric Diseases Caused by DOHaD TheoryAs (ncRNAs), including miRNAs, siRNAs, piRNAs, and lncRNAs, are functional RNA molecules that are transcribed from DNA but that are not translated into proteins. In general, miRNAs, siRNAs, and piRNAs function to regulate gene expression at the transcriptional and posttranscriptional levels. Studyin
发表于 2025-3-22 20:09:43 | 显示全部楼层
Placental Development and Nutritional Environments and oxygen to the fetus and receiving waste products, is the same in all mammals, the morphology of the placenta varies substantially in a species-dependent manner. Therefore, considerable interest exists in understanding placental development and function in mammals from a molecular biological vi
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