| 书目名称 | Development of New Radical Cascades and Multi-Component Reactions |
| 副标题 | Application to the S |
| 编辑 | Marie-Helene Larraufie |
| 视频video | |
| 概述 | Nominated as an outstanding Ph.D. thesis by the IPCM Université Pierre et Marie Curie, France.Honored with the French Chemical Society (SCF) - Organic Chemistry Section Ph. D. award for 2011.Presents |
| 丛书名称 | Springer Theses |
| 图书封面 |  |
| 描述 | In this dissertation, Marie-Hélène Larraufie develops original radical and pallado-catalyzed methodologies to enable the synthesis of several classes of bioactive nitrogen-containing heterocycles. New radical cascades employing the N-acylcyanamide moiety offer straightforward routes to quinazolinones and guanidines, as well as new insights into the mechanism of homolytic aromatic substitutions. In parallel, Larraufie expands the scope of visible light photoredox catalysis to the ring opening of epoxides and aziridines, thus providing new sustainable alternatives for the generation of radicals. Furthermore, in a collaborative effort with the Catellani group, the author investigates dual palladium/norbornene catalysis. First, she develops a C-amination coupling variant of the Catellani reaction with unprotected amines which provides an expeditious route to phenanthridines. Then, she examines the influence of the chelating effect on Pd(IV) intermediates reactivity with the help of experimental studies and DFT calculations. The work in this thesis has resulted in numerous publications in high impact journals.The clarity and depth of the experimental section will be useful for students |
| 出版日期 | Book 2014 |
| 关键词 | Aromatic Homolytic Substitution; Catellani Reaction; Cyanamides; Guanidines; Ortho Effect; Palladium IV; P |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-3-319-01324-4 |
| isbn_softcover | 978-3-319-37786-5 |
| isbn_ebook | 978-3-319-01324-4Series ISSN 2190-5053 Series E-ISSN 2190-5061 |
| issn_series | 2190-5053 |
| copyright | Springer International Publishing Switzerland 2014 |
发表于 2025-3-21 19:17:12
