Titlebook: Design, Analysis, and Interpretation of Genome-Wide Association Scans; Daniel O. Stram Book 2014 Springer Science+Business Media New York

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Coronation

Recessive

Topics in Quantitative Genetics,chapter focuses specifically on gaining a basic grounding in three general topics:.In addition to these concepts, several important tools for the investigation of linkage disequilibrium and of population heterogeneity are introduced: specifically data from the HapMap project and data manipulation an

Obliterate

An Introduction to Association Analysis,the phenotype is discrete (disease/no disease) then case–control methods, . and ., are typically utilized. . for generalized linear models is reviewed, and the ., ., and . tests are defined and discussed. The analysis of data from nuclear family-based designs is also briefly introduced. Issues regar

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septicemia

Haplotype Imputation for Association Analysis, a particular study. This chapter first reviews haplotype frequency estimation and .. It gives the details of EM estimation and haplotype imputation for a small number of SNPs using data from unrelated subjects and then considers the extension of this method to larger number of SNPs. The partition-l

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SNP Imputation for Association Studies,s that have been genotyped in a particular study. Imputed SNP analysis is in certain respects identical to haplotype analysis since the imputed SNPs are on specific haplotypes or haplotype combinations. Testing imputed SNPs as well as genotyped SNPs is thus simply a more focused kind of haplotype an

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Post-GWAS Analyses, one or more GWAS studies of a particular disease have been completed. These analyses include pooled or . used in order to combine results of two or more studies, typically with the help of the of large-scale SNP imputation as discussed in .. Additional analyses include replication of results often

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Design, Analysis, and Interpretation of Genome-Wide Association Scans978-1-4614-9443-0Series ISSN 1431-8776 Series E-ISSN 2197-5671