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Titlebook: Delivery Systems for Peptide Drugs; S. S. Davis,Lisbeth Illum,E. Tomlinson Book 1986 Springer Science+Business Media New York 1986 absorpt

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发表于 2025-3-21 19:50:18 | 显示全部楼层 |阅读模式
书目名称Delivery Systems for Peptide Drugs
编辑S. S. Davis,Lisbeth Illum,E. Tomlinson
视频video
丛书名称NATO Science Series A:
图书封面Titlebook: Delivery Systems for Peptide Drugs;  S. S. Davis,Lisbeth Illum,E. Tomlinson Book 1986 Springer Science+Business Media New York 1986 absorpt
描述Recent years have seen enormous advances in the field of protein and peptide engineering and a greater understanding in the way in which biological response modifiers function in the body. It is now possible through the use of recombinant DNA techniques, or by solid phase protein synthesis, to produce significant quantities of a wide variety of regulatory agents that are therapeutically applicable. The list of these response modifiers expands almost daily to include interferons, macrophage activation factors, neuropeptides and agents that may have potential in cardiovascular disease, inflammation, contraception etc. Prospects to use some of these materials in medicine have reached the stage where products have either been approved by regulatory authorities or are the subject of applications as investigatory drugs or as new therapeutic agents. In some uses the pertinent agent will be administered on an acute basis in the form of a simple injection, as, for example, the use of a tissue plasminogen activator for the treatment of coronary infarct. In other cases regulatory proteins and peptides are indicated for chronic therapy and here they will need to be administered by an appropria
出版日期Book 1986
关键词absorption; biotechnology; cardiovascular disease; drug; drug delivery; inflammation; interferon; life scie
版次1
doihttps://doi.org/10.1007/978-1-4757-9960-6
isbn_softcover978-1-4757-9962-0
isbn_ebook978-1-4757-9960-6
copyrightSpringer Science+Business Media New York 1986
The information of publication is updating

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发表于 2025-3-21 23:57:24 | 显示全部楼层
Vom Erkennen und Erfinden seiner selbst,es. Indeed, a number of these products, namely human insulin, human growth hormone and interferon alpha are now being marketed while others such as tissue plasminogen activator and hepatitis B vaccine are in advanced trials.
发表于 2025-3-22 01:40:35 | 显示全部楼层
Kinder brauchen (auch) die ‚Power Rangers‘-Ser (Bu.).-Azgly.-LHRH; ‘Zoladex’ is a trade mark, the property of Imperial Chemical Industries PLC). However the therapeutic and commercial potential of polypeptide drugs will only be realised if these advances are accompanied by dosage form design leading to practical and effective formulations.
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Intracellular Sorting of Proteins, (1) the eukaryotic secretory system; (2) the nucleus; (3) the mitochondria; (4) the chloroplasts; (5) the bacterial secretory system. The scope of this review does not allow in-depth treatment of all important aspects of protein sorting. For detailed reviews see Schekman (1985), Garoff (1985), Farquhar (1985) and Benson et al. (1985).
发表于 2025-3-22 11:04:08 | 显示全部楼层
The Oral Bioavailability of Peptides and Related Drugs,ptide drugs (for review see Humphrey & Ringrose, 1986). The purpose of this review is to describe the various barriers to, and mechanisms of absorption of peptide drugs, as well as, to discuss the relationship between physio-chemical properties and absorption (see Table 1).
发表于 2025-3-22 13:40:27 | 显示全部楼层
Der produktive Dialog als Verstehensmodellited for the absorption of drugs, especially those that are extensively metabolized in the gastrointestinal fluids and the gut wall or are subjected to an extensive first pass hepatic metabolism. The various regulatory peptides and proteins are good examples.
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Die Macht der Worte und der Medien been attributed to their potent pharmacological activity and their good biological tolerance. However, the disadvantages have been their broad pharmacological activity (which is often masked by a singular potent effect) and their relative short biological halflife (Table 1).
发表于 2025-3-23 07:34:13 | 显示全部楼层
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