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Titlebook: Deadly Dermatologic Diseases; Clinicopathologic At David R. Crowe,Michael Morgan,Kara Trapp Book 2016Latest edition Springer International

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Langerhans Cell Histiocytosisngerhans cells are dendritic antigen-presenting cells that normally reside within squamous epithelium, peri-epithelial connective tissue, and lymphatics and in areas of lymph node. Studies to date suggest that LCH is a heterogeneous disease with an unclear etiology. A clonal expansion of Langerhans
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Mast Cell Disease: Urticaria Pigmentosa organs, demonstrating the systemic involvement of mastocytosis. Most cases of urticaria pigmentosa are caused by a point mutation of the proto-oncogene c-kit at codon 816. C-kit functions as a transmembrane protein and is involved in signaling cell division when bound to mast cell growth factor. Mu
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