Titlebook: Deadenylation; Methods and Protocol Eugene Valkov,Aaron C. Goldstrohm Book 2024 This is a U.S. government work and not under copyright prot

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1064-3745 leshooting and avoiding known pitfalls... ..Authoritative and cutting-edge, .Deadenylation: Methods and Protocols .aims to pave the way for future investigations of the complex regulatory networks that control mRNA stability and expression..978-1-0716-3483-7978-1-0716-3481-3Series ISSN 1064-3745 Series E-ISSN 1940-6029

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Active, Recruiting Gene Therapy Studiesning fluorimetry (thermal shift assay) as a complementary assay that allows the direct characterization of ligand binding to deadenylase enzymes. The assays can be useful for the characterization of deadenylase variants and are particularly suitable for the discovery and development of small-molecule inhibitors of deadenylase enzymes.

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Franco M. Borrelli,Cecilia ChalliolA’s expression precisely and restores deficient protein levels to normal. This approach effectively increases the steady-state expression level of several transcripts associated with haploinsufficiency disorders in cell culture.

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