Titlebook: Data Monitoring in Clinical Trials; A Case Studies Appro David L. DeMets,Curt D. Furberg,Lawrence M. Friedm Book 2006 Springer-Verlag New Y

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The Essentials of Nursing Management Seriesomparing candesartan with placebo in patients with chronic heart failure (CHF) who (1) were intolerant to angiotensin converting enzyme (ACE)-inhibitor and had left ventricular ejection fraction (LVEF) ≤ 40%, (2)) were on ACE-inhibitor and had LVEF ≤ 40% or (3)) had LVEF > 40%. CHARM provides an int

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The Essentials of Nursing Management Seriesmplex process. It may involve, among other things, the need to (1) determine whether the observed treatment differences are likely to represent real effects and are not due to chance; (2) weigh the importance of different response variables, some possibly trending in favor of the treatment and some

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The Patient-Surgeon Relationships with a recent myocardial infarction would reduce the incidence of sudden death and total mortality, using three drugs known to suppress cardiac arrhythmias. Patients were randomized to receive either active drug or a matching placebo. The trial was terminated after only 15% of the planned-for even

Institution

Communication with Young Peoplestudies with milrinone, a cyclic AMP-enhancing positive inotropic agent. Earlier studies had shown positive effects of milrinone on cardiac function and exercise performance in patients with chronic heart failure. To determine the effect of milrinone on mortality, patients with severe chronic heart

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chapel

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The Patient-Surgeon Relationshipythmias. Patients were randomized to receive either active drug or a matching placebo. The trial was terminated after only 15% of the planned-for events had been observed with an unexpected but dramatic increase in sudden death and total mortality in those patients receiving two of the active therapies. Later, the third drug was also discontinued.

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