| 书目名称 | Data Mining in Structural Biology | | 副标题 | Signal Transduction | | 编辑 | I. Schlichting,U. Egner | | 视频video | | | 丛书名称 | Ernst Schering Foundation Symposium Proceedings | | 图书封面 |  | | 描述 | Structural biology is becoming a routine technique for structure de termination in pharmaceutical industries. The advances in molecular biology, crystal handling and data collection techniques, tunable syn chrotron radiation sources, and high-performance computing have all contributed to developments such as the production and expression of tailored protein domains, the use of the MAD (Multiple Anomalous Dispersion) method, and the collection of X-ray data from tiny crystals at cryogenic temperature. The number of protein structures deposited in the Protein Databank has increased tremendously over the last 3-4 years. Since 1997, more than 1,500 structures have been deposited each year, and during the first 7 months of this year, 1,500 protein structures were already deposited. The numerous initiatives in the field of "structural genomics" distributed all over the world have led to the development of techniques for high-throughput structure determina tion, thereby contributing to the increase in the determination of three dimensional protein structures. This structural information is being ex plored in various ways in the drug discovery process. It is not only used in structure | | 出版日期 | Conference proceedings 2001 | | 关键词 | DNA; Transcription Factors; biology; cell; cell cycle; data mining; drug design; protein; protein structure; | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-662-04645-6 | | isbn_softcover | 978-3-662-04647-0 | | isbn_ebook | 978-3-662-04645-6Series ISSN 0947-6075 | | issn_series | 0947-6075 | | copyright | Springer-Verlag Berlin Heidelberg 2001 |
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发表于 2025-3-21 19:08:50
