Titlebook: Damage-Associated Molecular Patterns in Human Diseases; Volume 1: Injury-Ind Walter Gottlieb Land Book 2018 Springer International Publishi

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Katharina Beier,Claudia Wiesemanndified DAMPs. Subclasses include nuclear DNA breaks, cytosolic mislocated/dislocated nuclear and mitochondrial DNA, cytosolic abnormally accumulating RNA, dyshomeostasis-associated perturbed molecular patterns such as reflected by intracellular potassium efflux, and accumulating metabolic molecules

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Das Recht auf Kenntnis der Abstammungodies, and galectins. Prominent candidates of modified molecules include actively secreted, processed interleukin-1 family members, processed high mobility group box 1, and anaphylatoxins. Subgroups of SAMPs refer to molecules known to contribute not to promotion but to resolution of inflammation. T

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Damage-Associated Molecular Patterns in Human DiseasesVolume 1: Injury-Ind

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Prologue: The Term “Immunity” over the Course of Timeetchnikoff in Russia holding that phagocytes play the dominant role in immune defense and the “humoral theory” proposed by Paul Ehrlich and Emil von Behring in Germany holding that a soluble substance in the body was mainly responsible for mediating immunity. Today it is known: both the “cellularist

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The Three Major Paradigms in Immunologyed from pathogens, the “pathogen-associated molecular patterns.” The recognition process then elicits an inflammatory anti-pathogen defense response. This model was again complemented and modified by Matzinger and Land now holding that the immune system does not discriminate between self and nonself

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