Titlebook: DNA Topoisomerases in Cancer Therapy; Present and Future Toshiwo Andoh Book 2003 Springer Science+Business Media New York 2003 DNA.biology.

断岩

书目名称DNA Topoisomerases in Cancer Therapy影响因子(影响力)




书目名称DNA Topoisomerases in Cancer Therapy影响因子(影响力)学科排名




书目名称DNA Topoisomerases in Cancer Therapy网络公开度




书目名称DNA Topoisomerases in Cancer Therapy网络公开度学科排名




书目名称DNA Topoisomerases in Cancer Therapy被引频次




书目名称DNA Topoisomerases in Cancer Therapy被引频次学科排名




书目名称DNA Topoisomerases in Cancer Therapy年度引用




书目名称DNA Topoisomerases in Cancer Therapy年度引用学科排名




书目名称DNA Topoisomerases in Cancer Therapy读者反馈




书目名称DNA Topoisomerases in Cancer Therapy读者反馈学科排名

傲慢物

绅士

foliage

Degradation of topoisomerase cleavable complexes,Pl, hTOP2a and hTOP2β, have been demonstrated to be important molecular targets for anticancer drugs (Liu, 1989; Wang, 1985; Wang, 1996; Chen and Liu, 1994; Hsiang and Liu, 1988; Zhang ., 2001; Li and Liu, 2001; Mao .., 1999; Nitiss and Wang, 1996; Kingma and Oscheroff, 1998).

消灭

Yeast as a model system in the analysis of DNA topoisomerase I poisons,anied by the formation of a covalent Top1-DNA intermediate, in which the active site tyrosine of Top1 is linked to a 3’ phosphoryl DNA end. This distinguishes type IB enzymes from other DNA topoisomerases, which form a 5’ phospho-tyrosyl linkage.

不来

Approaches to Artificial Intelligence,se II targeting agents act against the enzyme, what events following topoisomerase II inhibition are important for cytotoxicity, and how cells can elaborate resistance to topoisomerase II targeting agents.

不来

Understanding the action of drugs targeting TOP2: ,,se II targeting agents act against the enzyme, what events following topoisomerase II inhibition are important for cytotoxicity, and how cells can elaborate resistance to topoisomerase II targeting agents.

训诫

at Harvard University, contributed an article: `Reflections .In the mid 80‘s type I and II enzymes were found to be the intracellular targets of a number of efficacious anticancer drugs such as doxorubicin, mitoxantrone, etoposide and camptothecin as a result of a continued efforts of many investiga

flaunt

https://doi.org/10.1007/978-3-031-08743-1ing of the drug’s mechanism of action (5). The finding in 1985 that camptothecin specifically poisons top1 has generated great interest to find water-soluble, more efficacious and less toxic analogues of camptothecin.

脆弱带来

Gunay Kazimzade,Yasmin Patzer,Niels Pinkwartaction. The finding in 1985 that top1 was the target of camptothecin generated great interest to find water-soluble, more efficacious and less toxic analogues of camptothecin, and stimulated the search of non-camptothecin inhibitors (5, 6).