Titlebook: DNA Replication and the Cell Cycle; 43. Colloquium der G Ellen Fanning,Rolf Knippers,Ernst-L. Winnacker Conference proceedings 1993 Springe

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Eukaryotic Origins of DNA Replicationntral to control of the eukaryotic cell cycle (Laskey et al. 1989). In addition, initiation of DNA replication is coupled to programmed changes in gene expression that occur during the life of a single cell as well as during the development of multicellular organisms (Villarreal 1991). Therefore, un

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Protein-Induced Alterations in DNA Structure at the , Origin of Replication the DNA sequences that encompass the origin of replication associated with the Chinese hamster dihydrofolate reductase . gene. A variety of experimental approaches suggests that replication of amplified . genes in die methotrexate-resistant variant of CHO cells, CHOC 400, initiates within a 4.3 kb

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Mechanism and Control of Cellular DNA Replicationbility to compare and contrast the mechanisms of DNA synthesis and the functions of the replicative enzymes. In much the same way, studies of the mammalian DNA viruses have contributed to an understanding of the enzymology of cellular DNA replication. The choice model system to date for understandin

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The Mitogen/Oncogene-Activated p70s6k: Its Role in the G0/G1 Transitioncell division (Pardee 1989). One such process is the activation of protein synthesis which is required not only for the G./G. transition, but also for cells to progress through G. and initiate DNA synthesis (Brooks 1977; Rossow et al. 1979). This event is associated with the phosphorylation of a num

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Ubiquitin-Dependent Protein Degradationtachment of ubiquitin, a small (8.5 kDa) and highly conserved protein, to proteolytic substrates prior to degradation (for reviews see Hershko 1991; Finley and Chau 1991; Jentsch et al. 1991, Jentsch 1992a; Jentsch 1992b). This pathway is highly selective and mediates the elimination of abnormal pro

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Ternary Complex Formation at the Human c-, Serum Response Elementellular signalling pathway that leads to the rapid and transient transcriptional activation of a large family of genes, the so-called “immediate-early” genes (Almendrai et al. 1988; Bravo 1990). To attain a comprehensive understanding of cellular growth control will require the elucidation of the me